E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

Identified as the pathogenic genes of Alzheimer's disease (AD), APP, PSEN1, and PSEN2 mainly lead to early-onset AD, whose course is more aggressive, and atypical symptoms are more common than sporadic AD. Here, a novel missense mutation, APP E674Q (also named “Shanghai APP”), was detected in a...

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Bibliographic Details
Main Authors: Yongfang Zhang, Xinyi Xie, Boyu Chen, Lina Pan, Jianping Li, Wanbing Wang, Jintao Wang, Ran Tang, Qiang Huang, Xiaofen Chen, Rujing Ren, Zhentao Zhang, Wei Fu, Gang Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Genes and Diseases
Subjects:
Alzheimer's disease
Amyloid beta
APP mutation
E674Q
Late onset
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223001277

Internet

http://www.sciencedirect.com/science/article/pii/S2352304223001277

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