Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level

Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level

The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-2 to the receptor angiotensin II-converting enzyme 2 (ACE2) on the permiss...

Full description

Bibliographic Details
Main Authors: Jimin Wang, Federica Maschietto, Matthew J. Guberman-Pfeffer, Krystle Reiss, Brandon Allen, Yong Xiong, Elias Lolis, Victor S. Batista
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV2
Spike trimers
ACE2 dimer
Super-complex
Peptidase domain
Prefusion conformation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021003846

Internet

http://www.sciencedirect.com/science/article/pii/S2001037021003846

Similar Items