Regulation of MRI contrast and cellular retention time by cellular interfacial distribution of Gd agents: Implications for stem cell tracking

Regulation of MRI contrast and cellular retention time by cellular interfacial distribution of Gd agents: Implications for stem cell tracking

Human mesenchymal stem cells (hMSCs) were labeled with Dotarem or (Gd-DOTA)2- EM7 (EM7Gd2) via electroporation (EP). Cellular transmission electron microscopy (TEM) reveals free distribution of Gd agents and formation of EM7Gd2 clusters in the cytosol. Cellular magnetic resonance imaging (MRI) revea...

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Bibliographic Details
Main Authors: Yanhui Zhang, Binbin Li, Bo Tan, Hailu Zhang, Zongwu Deng
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-02-01
Series:Magnetic Resonance Letters
Subjects:
MRI
Gd agent
Cellular distribution
Relaxation rate
Intracellular retention time
Online Access:http://www.sciencedirect.com/science/article/pii/S2772516221000243

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http://www.sciencedirect.com/science/article/pii/S2772516221000243

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