A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family

A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family

Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of asthenozoospermia categorized by immotile spermatozoa with abnormal flagella in ejaculate. Whole-exome sequencing (WES) is used to detect pathogenic variants in patients with MMAF. In this study, a novel homozygous...

Full description

Bibliographic Details
Main Authors: Sobia Dil, Asad Khan, Ahsanullah Unar, Meng-Lei Yang, Imtiaz Ali, Aurang Zeb, Huan Zhang, Jian-Teng Zhou, Muhammad Zubair, Khalid Khan, Shun Bai, Qing-Hua Shi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Asian Journal of Andrology
Subjects:
dnah8; gene mutation; male infertility; multiple morphological abnormalities of the sperm flagella
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=3;spage=350;epage=355;aulast=

Internet

http://www.ajandrology.com/article.asp?issn=1008-682X;year=2023;volume=25;issue=3;spage=350;epage=355;aulast=

Similar Items