UGT1A1 Allele Test Not Only Minimizes the Toxicity But Also Maximizes the Therapeutic Effect of Irinotecan in the Treatment of Colorectal Cancer: A Narrative Review

UGT1A1 Allele Test Not Only Minimizes the Toxicity But Also Maximizes the Therapeutic Effect of Irinotecan in the Treatment of Colorectal Cancer: A Narrative Review

BackgroundIrinotecan is a first-line agent in the systematic treatment of colorectal cancer (CRC). Adjusting the dose of irinotecan according to the uridine diphosphate glucuronosyltransferase (UGT) 1A1 genotype reflects the principle of individualized and precision medicine, and may improve the che...

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Bibliographic Details
Main Authors: Yaoyuan Li, Honggang Zheng, Xiwen Zhang, Yupeng Xi, Mengqi Cheng, Yuwei Zhao, Liya Wang, Baojin Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
UGT1A1
irinotecan
colorectal cancer
systematic review
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.854478/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.854478/full

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