Calothrixin B derivatives induce apoptosis and cell cycle arrest on HEL cells through the ERK/Ras/Raf/MEK pathway

Calothrixin B derivatives induce apoptosis and cell cycle arrest on HEL cells through the ERK/Ras/Raf/MEK pathway

Background: Acute erythroleukemia (AEL) is acute myeloid leukemia characterized by malignant erythroid proliferation. AEL has a low survival rate, which has seriously threatened the health of older adults. Calothrixin B is a carbazole alkaloid isolated from the cyanobacteria Calothrix and exhibits a...

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Bibliographic Details
Main Authors: Bo Wang, Ming Wang, Ke Li, Chaoyan Wang, Xiang Liu, Qing Rao, Jingrui Song, Yubing Hang, Sheng Liu, Min Wen, Lei Huang, Yanmei Li
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Calothrisin B
Apoptosis
Cell cycle
ERK
Erythroleukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222400060X

Internet

http://www.sciencedirect.com/science/article/pii/S075333222400060X

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