Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study

Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study

BackgroundResistance to anti-tuberculous drugs is a major challenge in the treatment of tuberculosis (TB). We aimed to evaluate the clinical availability of nanopore-based targeted next-generation sequencing (NanoTNGS) for the diagnosis of drug-resistant tuberculosis (DR-TB).MethodsThis study enroll...

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Bibliographic Details
Main Authors: Aimei Liu, Sang Liu, Kangyan Lv, Qingdong Zhu, Jun Wen, Jianpeng Li, Chengyuan Liang, Xuegang Huang, Chunming Gong, Qingfeng Sun, Hongcang Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
drug-resistant tuberculosis
nanopore sequencing
mutation
molecular diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1349715/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1349715/full

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