Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose

Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose

Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model. However, it is still less clear if GO-Y022 affects tumor-induced immune suppression. In this study, we found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-β...

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Bibliographic Details
Main Authors: Takashi MaruYama, Hirofumi Miyazaki, Yun-Ji Lim, Jian Gu, Masaki Ishikawa, Taichi Yoshida, WanJun Chen, Yuji Owada, Hiroyuki Shibata
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
tumor microenvironment
stomach neoplasms
adenosine triphosphate
glycolysis
regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1049713/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1049713/full

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