Novel Antibody–Peptide Binding Assay Indicates Presence of Immunoglobulins against EGFR Phospho-Site S1166 in High-Grade Glioma

Novel Antibody–Peptide Binding Assay Indicates Presence of Immunoglobulins against EGFR Phospho-Site S1166 in High-Grade Glioma

We investigated the feasibility of detecting the presence of specific autoantibodies against potential tumor-associated peptide antigens by enriching these antibody–peptide complexes using Melon Gel resin and mass spectrometry. Our goal was to find tumor-associated phospho-sites that trigger immunor...

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Bibliographic Details
Main Authors: Lona Zeneyedpour, Christoph Stingl, Johan M. Kros, Peter A. E. Sillevis Smitt, Theo M. Luider
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
antibodies
tumor-specific antigen
Melon Gel
phospho-proteomics
mass spectrometry
Online Access:https://www.mdpi.com/1422-0067/23/9/5061

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https://www.mdpi.com/1422-0067/23/9/5061

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