Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp–/– Mice and Implications for Learning and Memory Deficits

Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp–/– Mice and Implications for Learning and Memory Deficits

Loss-of-function mutations in the gene that encodes TYRO protein kinase-binding protein (TYROBP) cause Nasu-Hakola disease, a heritable disease resembling Alzheimer’s disease (AD). Methylation of N6 methyl-adenosine (m6A) in mRNA plays essential roles in learning and memory. Aberrant m6A methylation...

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Bibliographic Details
Main Authors: Zhanyun Lv, Tongxiao Xu, Ran Li, Dejie Zheng, Yanxin Li, Wei Li, Yan Yang, Yanlei Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neuroscience
Subjects:
Tyrobp–/– mice
m6A methylation
METTL3
METTL14
WTAP
ALKBH5
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.739201/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.739201/full

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