The integrated single-cell analysis developed a lactate metabolism-driven signature to improve outcomes and immunotherapy in lung adenocarcinoma

The integrated single-cell analysis developed a lactate metabolism-driven signature to improve outcomes and immunotherapy in lung adenocarcinoma

BackgroundIt has been suggested that lactate metabolism (LM) is crucial for the development of cancer. Using integrated single-cell RNA sequencing (scRNA-seq) analysis, we built predictive models based on LM-related genes (LMRGs) to propose novel targets for the treatment of LUAD patients. MethodsTh...

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Bibliographic Details
Main Authors: Pengpeng Zhang, Shengbin Pei, Zeitian Gong, Qianhe Ren, Jiaheng Xie, Hong Liu, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
lung adenocarcinoma
lactate
signature
prognosis
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1154410/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1154410/full

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