Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process. Our knowledge of CNS EC development has been advanced largely by an...

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Bibliographic Details
Main Authors: Benjamin D Gastfriend, Hideaki Nishihara, Scott G Canfield, Koji L Foreman, Britta Engelhardt, Sean P Palecek, Eric V Shusta
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
human pluripotent stem cells
blood–brain barrier
Wnt signaling
endothelial cells
barriergenesis
Online Access:https://elifesciences.org/articles/70992

Internet

https://elifesciences.org/articles/70992

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