Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process. Our knowledge of CNS EC development has been advanced largely by an...
Main Authors: | Benjamin D Gastfriend, Hideaki Nishihara, Scott G Canfield, Koji L Foreman, Britta Engelhardt, Sean P Palecek, Eric V Shusta |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/70992 |
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