hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

Abstract Background Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neuron...

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Bibliographic Details
Main Authors: Roberta Schellino, Dario Besusso, Roberta Parolisi, Gabriela B. Gómez-González, Sveva Dallere, Linda Scaramuzza, Marta Ribodino, Ilaria Campus, Paola Conforti, Malin Parmar, Marina Boido, Elena Cattaneo, Annalisa Buffo
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Stem Cell Research & Therapy
Subjects:
Transplantation
Human embryonic stem cells
In vitro differentiation
Viral tracing
Medium spiny neurons
Direct and indirect pathways
Online Access:https://doi.org/10.1186/s13287-023-03422-4

Internet

https://doi.org/10.1186/s13287-023-03422-4

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