Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth

Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth

Novel targeted agents to inhibit DNA repair pathways to sensitize tumors to irradiation (IR) are being investigated as an alternative to chemoradiation for locally advanced human papilloma virus negative (HPV-negative) head and neck squamous cell carcinoma (HNSCC). Two well-characterized targets tha...

Full description

Bibliographic Details
Main Authors: Ling Zeng, Drexell Hunter Boggs, Chuan Xing, Zhuo Zhang, Joshua C. Anderson, Narendra Wajapeyee, Chris Veale, Markus Bredel, Lewis Z. Shi, James A. Bonner, Christopher D. Willey, Eddy S. Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Genetics
Subjects:
DNA repair
DNA damage
PARP inhibitors
DNA-PK inhibitors
non-homologous end-joining
homologous recombination
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.01036/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.01036/full

Similar Items