Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance

Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance

Ubiquitin-conjugating enzyme E2 C (UBE2C) plays a carcinogenic role in gastric cancer (GC); yet, its role in cisplatin (DDP) resistance in GC is enigmatic. This study sought to probe into the impact of UBE2C on DDP resistance in GC and its concrete molecular mechanism in GC progression. Bioinformati...

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Bibliographic Details
Main Authors: Long Jiegen, Zhu Bin, Tian Tao, Ren Linfei, Tao Yong, Zhu Haitao, Li Dengwei, Xu Yonghong
Format: Article
Language:English
Published: De Gruyter 2023-10-01
Series:Open Medicine
Subjects:
mybl2
ube2c
gastric cancer
dna damage
cisplatin resistance
Online Access:https://doi.org/10.1515/med-2023-0757

Internet

https://doi.org/10.1515/med-2023-0757

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