The Role of FBXW7 in Gynecologic Malignancies

The Role of FBXW7 in Gynecologic Malignancies

The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ub...

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Bibliographic Details
Main Authors: Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Sarah Suleiman, Mariela Vasileva-Slaveva, Angel Yordanov, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
FBXW7
ubiquitin-proteasome system
gynecologic cancers
epigenetic
mutations
miRNAs
Online Access:https://www.mdpi.com/2073-4409/12/10/1415

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https://www.mdpi.com/2073-4409/12/10/1415

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