The Role of FBXW7 in Gynecologic Malignancies
The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ub...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2073-4409/12/10/1415 |
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| author | Riccardo Di Fiore Sherif Suleiman Rosa Drago-Ferrante Yashwanth Subbannayya Sarah Suleiman Mariela Vasileva-Slaveva Angel Yordanov Francesca Pentimalli Antonio Giordano Jean Calleja-Agius |
| author_facet | Riccardo Di Fiore Sherif Suleiman Rosa Drago-Ferrante Yashwanth Subbannayya Sarah Suleiman Mariela Vasileva-Slaveva Angel Yordanov Francesca Pentimalli Antonio Giordano Jean Calleja-Agius |
| author_sort | Riccardo Di Fiore |
| collection | DOAJ |
| description | The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ubiquitin ligase. This complex aids in the degradation of many oncoproteins, such as cyclin E, c-JUN, c-MYC, NOTCH, and MCL1, via the ubiquitin-proteasome system (UPS). The FBXW7 gene is commonly mutated or deleted in numerous types of cancer, including gynecologic cancers (GCs). Such FBXW7 mutations are linked to a poor prognosis due to increased treatment resistance. Hence, detection of the FBXW7 mutation may possibly be an appropriate diagnostic and prognostic biomarker that plays a central role in determining suitable individualized management. Recent studies also suggest that, under specific circumstances, FBXW7 may act as an oncogene. There is mounting evidence indicating that the aberrant expression of FBXW7 is involved in the development of GCs. The aim of this review is to give an update on the role of FBXW7 as a potential biomarker and also as a therapeutic target for novel treatments, particularly in the management of GCs. |
| first_indexed | 2024-03-11T03:51:16Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T03:51:16Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Cells |
| spelling | doaj.art-f71999e77c974696b379322328405bd72023-11-18T00:53:17ZengMDPI AGCells2073-44092023-05-011210141510.3390/cells12101415The Role of FBXW7 in Gynecologic MalignanciesRiccardo Di Fiore0Sherif Suleiman1Rosa Drago-Ferrante2Yashwanth Subbannayya3Sarah Suleiman4Mariela Vasileva-Slaveva5Angel Yordanov6Francesca Pentimalli7Antonio Giordano8Jean Calleja-Agius9Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, MaltaDepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, MaltaBioDNA Laboratories, Malta Life Sciences Park, SGN 3000 San Gwann, MaltaSchool of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UKWhipps Cross Hospital, Barts Health NHS Trust, Leytonstone, London E11 1NR, UKDepartment of Breast Surgery, “Dr. Shterev” Hospital, 1330 Sofia, BulgariaDepartment of Gynecological Oncology, Medical University Pleven, 5800 Pleven, BulgariaDepartment of Medicine and Surgery, LUM University “Giuseppe DeGennaro”, 70010 Casamassima, ItalySbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USADepartment of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, MaltaThe F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which is a ubiquitin ligase. This complex aids in the degradation of many oncoproteins, such as cyclin E, c-JUN, c-MYC, NOTCH, and MCL1, via the ubiquitin-proteasome system (UPS). The FBXW7 gene is commonly mutated or deleted in numerous types of cancer, including gynecologic cancers (GCs). Such FBXW7 mutations are linked to a poor prognosis due to increased treatment resistance. Hence, detection of the FBXW7 mutation may possibly be an appropriate diagnostic and prognostic biomarker that plays a central role in determining suitable individualized management. Recent studies also suggest that, under specific circumstances, FBXW7 may act as an oncogene. There is mounting evidence indicating that the aberrant expression of FBXW7 is involved in the development of GCs. The aim of this review is to give an update on the role of FBXW7 as a potential biomarker and also as a therapeutic target for novel treatments, particularly in the management of GCs.https://www.mdpi.com/2073-4409/12/10/1415FBXW7ubiquitin-proteasome systemgynecologic cancersepigeneticmutationsmiRNAs |
| spellingShingle | Riccardo Di Fiore Sherif Suleiman Rosa Drago-Ferrante Yashwanth Subbannayya Sarah Suleiman Mariela Vasileva-Slaveva Angel Yordanov Francesca Pentimalli Antonio Giordano Jean Calleja-Agius The Role of FBXW7 in Gynecologic Malignancies Cells FBXW7 ubiquitin-proteasome system gynecologic cancers epigenetic mutations miRNAs |
| title | The Role of FBXW7 in Gynecologic Malignancies |
| title_full | The Role of FBXW7 in Gynecologic Malignancies |
| title_fullStr | The Role of FBXW7 in Gynecologic Malignancies |
| title_full_unstemmed | The Role of FBXW7 in Gynecologic Malignancies |
| title_short | The Role of FBXW7 in Gynecologic Malignancies |
| title_sort | role of fbxw7 in gynecologic malignancies |
| topic | FBXW7 ubiquitin-proteasome system gynecologic cancers epigenetic mutations miRNAs |
| url | https://www.mdpi.com/2073-4409/12/10/1415 |
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