Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

The mechanisms underlying the regenerative capacity of the liver are not fully understood. Here, the authors show that the acute regenerative response to liver injury in mice is regulated by the communication involving the vagus nerve, macrophages, and hepatocytes, leading to hepatic FoxM1 activatio...

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Bibliographic Details
Main Authors: Tomohito Izumi, Junta Imai, Junpei Yamamoto, Yohei Kawana, Akira Endo, Hiroto Sugawara, Masato Kohata, Yoichiro Asai, Kei Takahashi, Shinjiro Kodama, Keizo Kaneko, Junhong Gao, Kenji Uno, Shojiro Sawada, Vladimir V. Kalinichenko, Yasushi Ishigaki, Tetsuya Yamada, Hideki Katagiri
Format: Article
Language:English
Published: Nature Portfolio 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07747-0

Internet

https://doi.org/10.1038/s41467-018-07747-0

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