Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics

Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics

Enabling the implementation of top down proteomic techniques within clinical workflows requires a dramatic increase in sensitivity. It has been previously demonstrated that electrospray ionization (ESI) becomes more efficient with decreasing volumetric flow rates at the emitter. Therefore, narrow in...

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Bibliographic Details
Main Authors: Kyunggon Kim, Philip D. Compton, Timothy K. Toby, Paul M. Thomas, John T. Wilkins, R.Kannan Mutharasan, Neil L. Kelleher
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:EuPA Open Proteomics
Subjects:
Top down
Protein oxidation
Proteoforms
Electrospray ionization
Online Access:http://www.sciencedirect.com/science/article/pii/S2212968515300027

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http://www.sciencedirect.com/science/article/pii/S2212968515300027

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