Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells

Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells

Atherosclerosis is a chronic inflammatory disease and occurs preferentially in arterial regions exposed to disturbed blood flow (d-flow) while the stable flow (s-flow) regions are spared. D-flow induces endothelial inflammation and atherosclerosis by regulating endothelial gene expression partly thr...

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Bibliographic Details
Main Authors: Catherine Demos, Janie Johnson, Aitor Andueza, Christian Park, Yerin Kim, Nicolas Villa-Roel, Dong-Won Kang, Sandeep Kumar, Hanjoong Jo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
shear-sensitive TF
Sox13
CCL5
CXCL10
endothelium
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.979745/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.979745/full

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