Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease

Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease

In Alzheimer's disease (AD), potassium channel abnormalities have been reported in both neural and peripheral tissues. Herein, using whole-cell patch-clamp, we demonstrate an aberrant glutamate-dependent modulation of KV1.3 channels in T lymphocytes of AD patients. Although intrinsic KV1.3 prop...

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Bibliographic Details
Main Authors: Cornelia Poulopoulou, Ioannis Markakis, Panagiota Davaki, Eleftheria Tsaltas, Antonis Rombos, Alexandros Hatzimanolis, Dimitrios Vassilopoulos
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Potassium channels
Metabotropic glutamate receptors
T lymphocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002988

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http://www.sciencedirect.com/science/article/pii/S0969996109002988

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