Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

Tenascin C Has a Modest Protective Effect on Acute Lung Pathology during Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia in Mice

ABSTRACT Tenascin C (TNC) is an extracellular matrix protein with immunomodulatory properties that plays a major role during tissue injury and repair. TNC levels are increased in patients with pneumonia and pneumosepsis, and they are associated with worse outcomes. Methicillin-resistant Staphylococc...

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Bibliographic Details
Main Authors: Mariska T. Meijer, Alex F. de Vos, Hessel Peters Sengers, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Fabrice Uhel, Gertraud Orend, Tom van der Poll
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
tenascin C
Staphylococcus aureus
methicillin-resistant Staphylococcus aureus
pneumonia
alarmins
innate immunity
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00207-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00207-21

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