Lineage Reconstruction of In Vitro Identified Antigen-Specific Autoreactive B Cells from Adaptive Immune Receptor Repertoires

Lineage Reconstruction of In Vitro Identified Antigen-Specific Autoreactive B Cells from Adaptive Immune Receptor Repertoires

The emergence, survival, growth and maintenance of autoreactive (AR) B-cell clones, the hallmark of humoral autoimmunity, leave their footprints in B-cell receptor repertoires. Collecting IgH sequences related to polyreactive (PR) ones from adaptive immune receptor repertoire (AIRR) datasets make th...

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Bibliographic Details
Main Authors: Peter Blazso, Krisztian Csomos, Christopher M. Tipton, Boglarka Ujhazi, Jolan E. Walter
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
B cell lineage
autoreactive B cells
autoimmunity
AIRR
IgH repertoire
monoclonal antibody
Online Access:https://www.mdpi.com/1422-0067/24/1/225

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https://www.mdpi.com/1422-0067/24/1/225

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