DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice

DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice

Objectives: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth and metabolism. In mice, activation of mTOR controls cold adaptation by promoting the recruitment and the activation of brown adipose tissue (BAT). DEP-domain containing mTOR-interacting protein...

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Bibliographic Details
Main Authors: Charles Colas, Mathilde Mouchiroud, Manal Al Dow, Alona Kolnohuz, Yves Gélinas, Alexandre Caron, Mathieu Laplante
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Molecular Metabolism
Subjects:
DEPTOR
mTOR
brown adipocyte
brown adipose tissue
Adipogenesis
Thermogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002290

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822002290

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