CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC)

CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC)

(1) Background: HNSCC is a highly heterogeneous and relapse-prone form of cancer. We aimed to expand the immunological tool kit against HNSCC by conducting a functional screen to generate chimeric antigen receptor (CAR)-NK-92 cells that target HER1/epidermal growth factor receptor (EGFR). (2) Method...

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Bibliographic Details
Main Authors: Juliette Nowak, Marco Bentele, Ivana Kutle, Katharina Zimmermann, Jonathan Lukas Lühmann, Doris Steinemann, Stephan Kloess, Ulrike Koehl, Willi Roßberg, Amed Ahmed, Dirk Schaudien, Lavinia Neubert, Jan-Christopher Kamp, Mark P. Kuehnel, Athanasia Warnecke, Axel Schambach, Michael Morgan
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
chimeric antigen receptor
CAR-NK cells
NK-92 cells
HER1
EGFR
CD44v6
Online Access:https://www.mdpi.com/2072-6694/15/12/3169

Internet

https://www.mdpi.com/2072-6694/15/12/3169

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