Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor‐dependent contractions of guinea pig gastric fundus smooth muscle

Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor‐dependent contractions of guinea pig gastric fundus smooth muscle

Abstract The inhibitory effects of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and linoleic acid (LA) on the contractions induced by five prostanoids and U46619 (a TP receptor agonist) were examined in guinea pig gastric fundus smooth muscle (GFSM). Tension changes were isometrically me...

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Bibliographic Details
Main Authors: Keyue Xu, Miyuki Shimizu, Chika Murai, Miki Fujisawa, Daichi Ito, Noboru Saitoh, Yutaka Nakagome, Mio Yamashita, Azusa Murata, Shunya Oikawa, Guanghan Ou, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Pharmacology Research & Perspectives
Subjects:
docosahexaenoic acid
eicosapentaenoic acid
gastric fundus smooth muscle
n−3 polyunsaturated fatty acids
prostanoid TP receptor
prostanoids
Online Access:https://doi.org/10.1002/prp2.952

Internet

https://doi.org/10.1002/prp2.952

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