Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity were followed by immunocytochemistry and transmission electron microscopy....

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Bibliographic Details
Main Authors: Julianna Kobolak, Annamaria Teglasi, Tamas Bellak, Zofia Janstova, Kinga Molnar, Melinda Zana, Istvan Bock, Lajos Laszlo, Andras Dinnyes
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
induced pluripotent stem cells
neurospheres
3D culture
neurite outgrowth
neurotoxicity
Online Access:https://www.mdpi.com/2073-4409/9/5/1122

Internet

https://www.mdpi.com/2073-4409/9/5/1122

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