Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Abstract Background Despite emerging evidence on the therapeutic potential of mesenchymal stem cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC-derived exosomes (MSC-EXOs) are widely accepted as crucial messengers for intercellular communication. This study...

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Bibliographic Details
Main Authors: Siyuan Tian, Xia Zhou, Miao Zhang, Lina Cui, Bo Li, Yansheng Liu, Rui Su, Keshuai Sun, Yinan Hu, Fangfang Yang, Guoyun Xuan, Shuoyi Ma, Xiaohong Zheng, Xinmin Zhou, Changcun Guo, Yulong Shang, Jingbo Wang, Ying Han
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Liver fibrosis
Mesenchymal stem cells
Exosome
miR-148a
Macrophage polarization
Online Access:https://doi.org/10.1186/s13287-022-03010-y

Internet

https://doi.org/10.1186/s13287-022-03010-y

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