Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching

Brain-Derived Neurotrophic Factor (BDNF) Regulates Rab5-Positive Early Endosomes in Hippocampal Neurons to Induce Dendritic Branching

Neurotrophin receptors use endosomal pathways for signaling in neurons. However, how neurotrophins regulate the endosomal system for proper signaling is unknown. Rabs are monomeric GTPases that act as molecular switches to regulate membrane trafficking by binding a wide range of effectors. Among the...

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Bibliographic Details
Main Authors: Guillermo Moya-Alvarado, Andres Gonzalez, Nicolas Stuardo, Francisca C. Bronfman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurotrophins
BDNF
TrkB
Rab5
Rab11
endosomes
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00493/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00493/full

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