Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
Melatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03556-w |