Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
Melatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03556-w |
| _version_ | 1811334660844683264 |
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| author | Zhengtai Chen Hongqiang Wu Jianxin Yang Baolong Li Jian Ding Sheng Cheng Nageeb Bsoul Chenxi Zhang jiaorong li Haixiao Liu Damu Lin Weiyang Gao |
| author_facet | Zhengtai Chen Hongqiang Wu Jianxin Yang Baolong Li Jian Ding Sheng Cheng Nageeb Bsoul Chenxi Zhang jiaorong li Haixiao Liu Damu Lin Weiyang Gao |
| author_sort | Zhengtai Chen |
| collection | DOAJ |
| description | Melatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo. |
| first_indexed | 2024-04-13T17:11:22Z |
| format | Article |
| id | doaj.art-f73ccf6d13be416fa3ff2c376335aefa |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T17:11:22Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f73ccf6d13be416fa3ff2c376335aefa2022-12-22T02:38:16ZengNature PortfolioCommunications Biology2399-36422022-06-015111410.1038/s42003-022-03556-wActivating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survivalZhengtai Chen0Hongqiang Wu1Jianxin Yang2Baolong Li3Jian Ding4Sheng Cheng5Nageeb Bsoul6Chenxi Zhang7jiaorong li8Haixiao Liu9Damu Lin10Weiyang Gao11Department of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Number 6 Hospital of NingboWenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityMelatonin induces Parkin 1 dependent mitophagy in human umbilical vein endothelial cells through the AMPK/TFEB pathway, alleviating oxidative stress and apoptosis, which also enables skin flap survival in vivo.https://doi.org/10.1038/s42003-022-03556-w |
| spellingShingle | Zhengtai Chen Hongqiang Wu Jianxin Yang Baolong Li Jian Ding Sheng Cheng Nageeb Bsoul Chenxi Zhang jiaorong li Haixiao Liu Damu Lin Weiyang Gao Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival Communications Biology |
| title | Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival |
| title_full | Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival |
| title_fullStr | Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival |
| title_full_unstemmed | Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival |
| title_short | Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival |
| title_sort | activating parkin dependent mitophagy alleviates oxidative stress apoptosis and promotes random pattern skin flaps survival |
| url | https://doi.org/10.1038/s42003-022-03556-w |
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