Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells

Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells

Phosphorothioate (PS) group is a key component of a majority of FDA approved oligonucleotide drugs that increase stability to nucleases whilst maintaining interactions with many proteins, including RNase H in the case of antisense oligonucleotides (ASOs). At the same time, uniform PS modification in...

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Bibliographic Details
Main Authors: O. Sergeeva, E. Akhmetova, S. Dukova, E. Beloglazkina, A. Uspenskaya, A. Machulkin, D. Stetsenko, T. Zatsepin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Chemistry
Subjects:
ASO
alkanesulfonyl phosphoramidate
PSMA
prostate cancer
MALAT1 lncRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1342178/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2024.1342178/full

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