Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B domain, a MUN domain and a C2C domain. Munc13-1 was proposed to bridge synaptic vesicles to the plasma membrane through d...

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Bibliographic Details
Main Authors: Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
Munc13
neurotransmitter release
synaptic vesicle fusion
presynaptic plasticity
Online Access:https://elifesciences.org/articles/72030

Internet

https://elifesciences.org/articles/72030

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