Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts

Abstract UV exposure induces a mutation signature of C > T substitutions at dipyrimidines in skin cancers. We recently identified additional UV-induced AC > TT and A > T substitutions that could respectively cause BRAF V600K and V600E oncogenic mutations. The mutagenic bypass mechanism past...

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Bibliographic Details
Main Authors: Brittany N. Vandenberg, Marian F. Laughery, Cameron Cordero, Dalton Plummer, Debra Mitchell, Jordan Kreyenhagen, Fatimah Albaqshi, Alexander J. Brown, Piotr A. Mieczkowski, John J. Wyrick, Steven A. Roberts
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38255-5

Internet

https://doi.org/10.1038/s41467-023-38255-5

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