Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma

Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma

Abstract Background Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibiting the Solute Carrier family 7 member 11 (SLC7A11...

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Main Authors: Youmei Xiao, Zhanxue Xu, Yuan Cheng, Rufan Huang, Yuan Xie, Hsiang-i Tsai, Hualian Zha, Lifang Xi, Kai Wang, Xiaoli Cheng, Yanfeng Gao, Changhua Zhang, Fang Cheng, Hongbo Chen
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-07-01
Series:Biomaterials Research
Subjects:
Transferrin
Biomembrane-based nanovesicles
Sorafenib
Ferroptosis
Hepatocellular carcinoma
Combination therapy
Online Access:https://doi.org/10.1186/s40824-023-00401-x

Internet

https://doi.org/10.1186/s40824-023-00401-x

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