Downregulation of miR-211-5p Promotes Carboplatin Resistance in Human Retinoblastoma Y79 Cells by Affecting the GDNF–LIF Interaction

Downregulation of miR-211-5p Promotes Carboplatin Resistance in Human Retinoblastoma Y79 Cells by Affecting the GDNF–LIF Interaction

PurposeTo investigate the role of the miR-211-5p-GDNF signaling pathway in carboplatin resistance of retinoblastoma Y79 cells and what factors it may be affected by.MethodsA carboplatin-resistant retinoblastoma cell line (Y79R) was established in vitro. RNA-seq and microRNA-seq were constructed betw...

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Bibliographic Details
Main Authors: Ning Ke, Lin Chen, Qing Liu, Haibo Xiong, Xinke Chen, Xiyuan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
retinoblastoma
carboplatin resistance
miR-211-5p
glial cell-derived neurotrophic factor (GDNF)
leukemia inhibitory factor (ILF)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.848733/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.848733/full

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