Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy

Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy

Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a source of therapeutic resistance. In this study, we...

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Bibliographic Details
Main Authors: Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47412-1

Internet

https://doi.org/10.1038/s41598-023-47412-1

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