Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th17 polarization during infection

Mycobacterium tuberculosis impedes CD40-dependent notch signaling to restrict Th17 polarization during infection

Summary: Early Th17 responses are necessary to provide protection against Mycobacterium tuberculosis (Mtb). Mtb impedes Th17 polarization by restricting CD40 co-stimulatory pathway on dendritic cells (DCs). We previously demonstrated that engaging CD40 on DCs increased Th17 responses. However, the m...

Full description

Bibliographic Details
Main Authors: Ana Beatriz Enriquez, Jonathan Kevin Sia, Hedwin Kitdorlang Dkhar, Shu Ling Goh, Melanie Quezada, Kristina Larrieux Stallings, Jyothi Rengarajan
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Molecular biology
Parasitology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222005752

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222005752

Similar Items