Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells

Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells

Abstract Engineered T cells have been shown to be highly effective in cancer immunotherapy, although T cell exhaustion presents a challenge for their long-term function. Additional T-cell sources must be exploited to broaden the application of engineered T cells for immune defense and reconstitution...

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Bibliographic Details
Main Authors: Rongqun Guo, Wei Li, Yadan Li, Yingmei Li, Zhongxing Jiang, Yongping Song
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Experimental Hematology & Oncology
Subjects:
T-cell generation
Pluripotent stem cells
Conventional T cells
Engineered T cells
Gene editing
Online Access:https://doi.org/10.1186/s40164-022-00285-y

Internet

https://doi.org/10.1186/s40164-022-00285-y

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