The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in <i>Staphylococcus aureus</i>

The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in <i>Staphylococcus aureus</i>

Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in <i>S. aureus</i> using fluctuation analysis at 4 × minimum inh...

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Bibliographic Details
Main Authors: Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antibiotics
Subjects:
Corallopyronin A
<i>Staphylococcus aureus</i>
rifampicin
mutation frequency
mutation rate
natural product
Online Access:https://www.mdpi.com/2079-6382/11/7/920

Internet

https://www.mdpi.com/2079-6382/11/7/920

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