The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis

The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis

Cholesterol-24-hydroxylase (CH24H or Cyp46a1) is a reticulum-associated membrane protein that plays an irreplaceable role in cholesterol metabolism in the brain and has been well-studied in several neuro-associated diseases in recent years. In the present study, we found that CH24H expression can be...

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Bibliographic Details
Main Authors: Yueming Yuan, An Fang, Zongmei Wang, Zhihui Wang, Baokun Sui, Yunkai Zhu, Yuan Zhang, Caiqian Wang, Rong Zhang, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Redox Biology
Subjects:
CH24H
24HC
Neuroinvasive virus
Multivesicular body/late endosome
Cholesterol metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001702

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http://www.sciencedirect.com/science/article/pii/S2213231723001702

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