Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide

Abstract Background Although protein-based methods using cell-penetrating peptides such as TAT have been expected to provide an alternative approach to siRNA delivery, the low efficiency of endosomal escape of siRNA/protein complexes taken up into cells by endocytosis remains a problem. Here, to ove...

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Bibliographic Details
Main Authors: Momoko Nakamura, Kei Fujiwara, Nobuhide Doi
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Nanobiotechnology
Subjects:
Online Access:https://doi.org/10.1186/s12951-022-01667-4