Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes

Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes

The endosymbiotic theory proposes that eukaryotes evolved from the symbiotic relationship between anaerobic (host) and aerobic prokaryotes. Through iterative genetic transfers, the mitochondrial and nuclear genomes coevolved, establishing the mitochondria as the hub of oxidative metabolism. To study...

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Bibliographic Details
Main Authors: Richard Sejour, Roger A. Sanguino, Monika Mikolajczak, Walishah Ahmadi, Eugenia Villa-Cuesta
Format: Article
Language:English
Published: Oxford University Press 2020-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
sirt4
tor pathway
coevolution mtdna/ndna
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401174

Internet

http://g3journal.org/lookup/doi/10.1534/g3.120.401174

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