Enhancement of Anti-Tumoral Properties of Paclitaxel Nano-Crystals by Conjugation of Folic Acid to Pluronic F127: Formulation Optimization, In Vitro and In Vivo Study

Enhancement of Anti-Tumoral Properties of Paclitaxel Nano-Crystals by Conjugation of Folic Acid to Pluronic F127: Formulation Optimization, In Vitro and In Vivo Study

A brand-new nano-crystal (NC) version of the hydrophobic drug Paclitaxel (PT) were formulated for cancer treatment. A stable NC formulation for the administration of PT was created using the triblock co-polymer Pluronic F127. To achieve maximum entrapment effectiveness and minimal particle size, the...

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Bibliographic Details
Main Authors: Nagaraja Sreeharsha, Samathoti Prasanthi, Satyavarapu Veera Venkata Naga Satya Mahalakshmi, Prakash S. Goudanavar, Nimbagal Raghavendra Naveen, Buduru Gowthami, Santosh Fattepur, Girish Meravanige, Syed Mohammed Basheeruddin Asdaq, Md. Khalid Anwer, Bandar Aldhubiab, Mohammed Monirul Islam, Mohammed Habeebuddin, Mallikarjun Telsang, Mazen Al Gharsan, Michelyne Haroun
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
nano-crystals
Paclitaxel
anti-cancer
optimization
central composite design
Online Access:https://www.mdpi.com/1420-3049/27/22/7914

Internet

https://www.mdpi.com/1420-3049/27/22/7914

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