Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma

Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma

Mutations in Human Epidermal Growth Factor Receptors (HER) are associated with poor prognosis of several types of solid tumors. Although HER-mutation detection methods are currently available, such as Next-Generation Sequencing (NGS), alternative pyrosequencing allow the rapid characterization of sp...

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Bibliographic Details
Main Authors: Paula González-Alonso, Cristina Chamizo, Víctor Moreno, Juan Madoz-Gúrpide, Nerea Carvajal, Lina Daoud, Sandra Zazo, Ester Martín-Aparicio, Ion Cristóbal, Raúl Rincón, Jesús García-Foncillas, Federico Rojo
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
HER2
HER3
cancer
pyrosequencing
Online Access:http://www.mdpi.com/1422-0067/16/8/19447

Internet

http://www.mdpi.com/1422-0067/16/8/19447

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