B7-H3-targeted CAR T cell activity is enhanced by radiotherapy in solid cancers

B7-H3-targeted CAR T cell activity is enhanced by radiotherapy in solid cancers

Adoptive cell therapy utilizing T cells genetically modified to express a chimeric antigen receptor (CAR) has demonstrated promising clinical results in hematological malignancies. However, solid cancers have not seen a similar success due to multiple obstacles. Investigating these escape mechanisms...

Full description

Bibliographic Details
Main Authors: Marco Ventin, Giulia Cattaneo, Luke Maggs, Jingyu Jia, Shahrzad Arya, Soldano Ferrone, Xinhui Wang, Cristina R. Ferrone
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
immunotherapy
radiotherapy
solid cancer
combinatorial therapy
B7-H3 CAR T
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1193963/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1193963/full

Similar Items