Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

The accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A<sub>1</sub> receptor antagonist rolofylline (KW-3902) has previously been shown to reverse spatial...

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Bibliographic Details
Main Authors: Marta Anglada-Huguet, Heike Endepols, Astrid Sydow, Ronja Hilgers, Bernd Neumaier, Alexander Drzezga, Senthilvelrajan Kaniyappan, Eckhard Mandelkow, Eva-Maria Mandelkow
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
tau protein
Alzheimer’s disease
rolofylline
adenosine A1 receptor
behavior
synapses
Online Access:https://www.mdpi.com/1422-0067/24/11/9260

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https://www.mdpi.com/1422-0067/24/11/9260

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