Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the Processability of Polyvinyl Alcohol-Based Systems during Hot Melt Extrusion

Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the Processability of Polyvinyl Alcohol-Based Systems during Hot Melt Extrusion

Hot melt extrusion (HME) is a common manufacturing process used in the pharmaceutical industry to improve the solubility of poorly soluble active pharmaceutical ingredients (API). The goal is to create an amorphous solid dispersion (ASD) where the amorphous form of the API is stabilized within a pol...

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Bibliographic Details
Main Authors: Florian Hess, Thomas Kipping, Werner Weitschies, Julius Krause
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
hot melt extrusion
polyvinyl alcohol
plasticizer
filaments
mechanical properties
viscosity
Online Access:https://www.mdpi.com/1999-4923/16/4/472

Internet

https://www.mdpi.com/1999-4923/16/4/472

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