Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin

Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin

IntroductionFor decades, functional primary human osteocyte cultures have been crucially needed for understanding their role in bone anabolic processes and in endocrine phosphate regulation via the bone-kidney axis. Mature osteocyte proteins (sclerostin, DMP1, Phex and FGF23) play a key role in vari...

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Bibliographic Details
Main Authors: Helen J. Knowles, Anastasios Chanalaris, Argyro Koutsikouni, Adam P. Cribbs, Liam M. Grover, Philippa A. Hulley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
osteocyte
sclerostin
FGF23
mineralization
osteoclast
organoid
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1167734/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1167734/full

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